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It really is removed predominantly by hepatic metabolism (mostly CYP3A4) and it is converted to an Lively metabolite with Qualities just like the mum or dad, sildenafil. Each sildenafil plus the metabolite have terminal half lives of about 4 hours.

Explain to your physician In case you are pregnant or prepare to be pregnant through treatment with Viagra. It can be unknown if Viagra passes into breast milk or if it could hurt a nursing little one. Consult your doctor just before breastfeeding.

Your health practitioner received’t prescribe Viagra in case you’re using a nitrate drug. Having these medicines jointly may result in dangerously very low hypertension.

The indicate profiles with the adjust from baseline in standing systolic blood pressure in subjects addressed with doxazosin together with 50 mg VIAGRA or matching placebo are proven in Figure three.

Medical info have shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about three fold [see DRUG INTERACTIONS and Medical PHARMACOLOGY].

Doctors really should advise individuals to stop use of all phosphodiesterase type five (PDE5) inhibitors, which include VIAGRA, and search for health care interest during the occasion of the sudden loss of vision in one or each eyes. These kinds of an occasion may be a indication of non-arteritic anterior ischemic optic neuropathy (NAION), a uncommon situation along with a cause of decreased eyesight which includes everlasting lack of read more eyesight, which has been documented almost never post-promoting in temporal association with the use of all PDE5 inhibitors.

The typical starting off dose of Viagra is fifty mg. But your health care provider might prescribe a decreased setting up dosage of twenty five mg based on several factors. You'll want to adhere to your medical doctor’s dosing Guidelines.

Mean sildenafil plasma concentrations measured following the administration of one oral dose of one hundred mg to balanced male volunteers is depicted beneath:

In the event your hypertension is too minimal, your physician can provide you with drugs or fluids that will help increase your blood pressure.

 It really is useful for the remedy of erectile dysfunction (male impotence). It can help to obtain and retain an erection sufficient for sexual exercise.

Physicians should explore with individuals the increased risk of NAION in individuals who have already expert NAION in one eye. Doctors must also talk about with clients the elevated possibility of NAION among the the overall populace in people using a “crowded” optic disc, Whilst evidence is inadequate to aid screening of prospective consumers of PDE5 inhibitor, including VIAGRA, for this uncommon issue [see WARNINGS AND Safeguards and ADVERSE REACTIONS].

Driving: Sildenafil may possibly trigger dizziness or short-term vision variations, influencing your power to travel or work machinery. Keep away from driving, running machinery, or executing other perhaps hazardous responsibilities until you've determined how this medication has an effect on you.

If you have kidney issues, go over using your health care provider how this medication may possibly have an affect on your professional medical condition, how your medical ailment may perhaps have an effect on the dosing and usefulness of the medication, and irrespective of whether any Exclusive monitoring is necessary.

In Individuals individuals already getting an optimized dose of the PDE5 inhibitor, alpha-blocker therapy needs to be initiated at the lowest dose. Stepwise rise in alpha-blocker dose may very well be related to even more decreasing of hypertension when using a PDE5 inhibitor.